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Introduction: Reducing sedentary time is associated with improved postprandial glucose regulation. However, it is not known if the timing of sedentary behavior (i.e., pre- vs. postmeal) differentially impacts postprandial glucose in older adults with overweight or obesity.Methods: In this secondary analysis, older adults (≥65 years) with overweight and obesity (body mass index ≥ 25 kg/m²) wore a continuous glucose monitor and a sedentary behavior monitor continuously in their real-world environments for four consecutive days on four separate occasions. Throughout each 4-day measurement period, participants followed a standardized eucaloric diet and recorded mealtimes in a diary. Glucose, sedentary behavior, and meal intake data were fused using sensor and diary timestamps. Mixed-effect linear regression models were used to evaluate the impact of sedentary timing relative to meal intake.Results: Premeal sedentary time was significantly associated with both the increase from premeal glucose to the postmeal peak (ΔG) and the percent of premeal glucose increase that was recovered 1-hr postmeal glucose peak (%Baseline Recovery;p < .05), with higher levels of premeal sedentary time leading to both a larger ΔGand a smaller %Baseline Recovery. Postmeal sedentary time was significantly associated with the time from meal intake to glucose peak (ΔT;p < .05), with higher levels of postmeal sedentary time leading to a longer time to peak.Conclusions: Pre- versus postmeal sedentary behavior differentially impacts postprandial glucose response in older adults with overweight or obesity, suggesting that the timing of sedentary behavior reductions might play an influential role on long-term glycemic control. 

Abstract Regular exercise promotes whole-body health and prevents disease, but the underlying molecular mechanisms are incompletely understood^1–3. Here, the Molecular Transducers of Physical Activity Consortium⁴profiled the temporal transcriptome, proteome, metabolome, lipidome, phosphoproteome, acetylproteome, ubiquitylproteome, epigenome and immunome in whole blood, plasma and 18 solid tissues in male and femaleRattus norvegicusover eight weeks of endurance exercise training. The resulting data compendium encompasses 9,466 assays across 19 tissues, 25 molecular platforms and 4 training time points. Thousands of shared and tissue-specific molecular alterations were identified, with sex differences found in multiple tissues. Temporal multi-omic and multi-tissue analyses revealed expansive biological insights into the adaptive responses to endurance training, including widespread regulation of immune, metabolic, stress response and mitochondrial pathways. Many changes were relevant to human health, including non-alcoholic fatty liver disease, inflammatory bowel disease, cardiovascular health and tissue injury and recovery. The data and analyses presented in this study will serve as valuable resources for understanding and exploring the multi-tissue molecular effects of endurance training and are provided in a public repository (https://motrpac-data.org/).